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Discussion Starter #1
I have an approx 2.5 year-old, spayed, female, basset mix rescued 1.5 years ago. I've noticed that she will quite often leave a wet spot when napping soundly (or perhaps when waking) on her bed or on her blanket on the couch beside me. She has had a wet bed overnight, but the problem seems to occur more frequently during the day. It is annoying since I have tried to be very regular about taking her out every 2-3 hours during the day when I am home. For the last couple of months, I have been getting up to take her out at 2, 3, or 4 AM, so maybe that's why no wet spots at night?
It seemed to be getting much worse after she went off antibiotics for a serious skin infection on her nose in Dec. I took her to the vet to check for UTI, though she doesn't squat frequently outside that would indicate a UTI. Upon checking her urine (twice), it was discovered to be dilute (without infection or crystals). Bloodwork indicated good kidney function. A visit to a specialist, ultrasound, and more bloodwork shows that she tests positive for leptospirosis and has an enlarged spleen. She has now been on doxycyline for 10 days. (She's also been taking hormone DES now every 8 days.). She still wets when napping. She is crated for 4-5-hour intervals during the day, and it isn't apparent that she wets on the plastic floor of the crate. Also, she exhibits no real urgency in needing to pee when she goes out after being crated.
Does anyone have any thoughts about this? It seems like testing positive for the lepto may be a secondary find and not related to the bed wetting. Any suggestions? She goes back for a recheck of blood and ultrasound in a couple of weeks. I'm happy that she isn't showing any real sickness with the lepto, but it seems that the initial reason I took her to the vet isn't resolved.
 

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This is all very odd.

Has she ever been Lepto vaccinated? Lepto dogs tend to be very sick a dying essentially.

Was the urine actually cultured?

Liver values normal as well as kidneys? If so, why did they test for Lepto?

None of this makes a lot of sense to me...
 

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Thanks for your reply. She has been vac twice for lepto since I've had her (once in 2012 and again last summer), but I've been told that it doesn't cover all strains (and she tested positive for 2 of the 4). The vaccine can cause a dog to test positive, though? Liver wasn't mentioned, so I assume normal. Kidneys also looked ok. Ultrasound was done just to make sure no congenital defect to kidneys. Spleen enlarged--I assume the ultrasound would have shown a tumor or cancer of spleen? Would a urine culture show infection or something else? Urine didn't show infection or crystals, just dilute. And Dolly doesn't present like she has a UTI--not frequent (well, except for every 2-3 hours, but she goes once or twice and then is done.) and not urgent. Is it possible that the spleen is enlarged because she's been fighting an infection for months? Vaccine made her fight the lepto. Could spleen be pressing when she lies in certain positions, which is causing the now and then wetting? Is there anything I could try doing while I wait. I'm doing DES every 8 days and doxycycline 2x/day.
 

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The skin infection on her nose in Oct was very strange. It came on very suddenly as a bloody, pussy, mess. It looked like a dozen or more pomegranate seeds piled up around her black nose but in her white fur as well. Fur is just filling in in the last few weeks. Theory that she was fighting something and had a low immune that made this come on so bad? She really doesn't act sick. She is a basset so sleeps a lot, but I haven't noticed any change this fall. (She did seem pretty miserable with the nose thing, but that was only the first day or so.)
 

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My dog had her follow up exam a week ago. Spleen was smaller/urine still dilute. Blood test just came back and doesn't show any change in the lepto level, so it's not likely that she has had a recent exposure to lepto. (Another adrenal gland test was done and that was normal.) Vet still thinks she might have suffered some kidney damage which would explain incontinence and dilute urine.
Meanwhile, dog is off the DES (she was scheduled to have one 3 days ago and no accidents). She has wet her bed at night only twice in about a month and hasn't peed while napping. She usually gets me up once in the night and I let her go out and pee, which she does efficiently. But I don't know if she gets up because she is bored, there is good wildlife in yard, or she really HAS to go. Vet wants me to come back for another appt in 3 weeks, but what now? Except for the urinary incontinence which has improved since early Dec for some unknown reason, dog is perfectly healthy. I feel like I've spent enough and ruled out some big things. Thoughts? This is an internal medicine specialist vet. Obviously, I'd take her back to her regular vet when she is due in June or back to the specialist if dog becomes worse or sick.
 

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It may be a good idea for you to get treated for lepto yourself. Leptospirosis can kill you. My dog died from leptospirosis and everyone in the house had to go on antibiotics immediately. Just cleaning the urine is enough to get you exposed. You need to bleach/disinfect everything that has been urinated on. Get rid of her dog beds and get news ones.

You are VERY lucky your dog is alive. My dog died in 3 days from leptospirosis and it was so bad his kidneys hemorrhaged. He had been perfectly healthy 3 days prior. Unfortunately the vets around here never mentioned the vaccine and I did not think he was at risk (no standing water on the property).

I would also assume your dog has some kidney damage. I think 10 days of doxycycline is not enough. I read online that animals can become chronic carriers and pass it in their urine for months. You need to treat with antibiotics for so long to eliminate the carrier state.

I just looked it up:

To clear renal infections and eliminate the carrier state and chronic shedding, doxycyline should be administered for 3 weeks once oral medication is possible, or if doxycycline is not tolerated, a fluoroquinolone can be administered in conjunction with a penicillin derivative.

For acute cases, the recommendation is 3 weeks of amoxicillin and 3 weeks of doxycycline. IV fluids and medications to help with nausea are very important.

Identifying dogs shedding leptospires allow veterinarians, their staff and the pet owner to take appropriate precautions (e.g.,
latex gloves, face mask, goggles) when handling the dog’s
urine and urine contaminated areas.

Thorough hand washing, avoiding contact with urine, wearing gloves when cleaning potentially infected material and avoiding spraying water when cleaning to avoid aerosolizing the bacteria will limit the infection risk.


Most common disinfectants kill leptospires including bleach, povidone-iodine, and chlorhexadine.
 

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4horses,
Thanks so much for your reply! I'm terribly sorry to hear about your dog. :-(( Because lepto is often deadly, it has been a questionmark as to whether it is causing my Dolly's problems. (Maybe the vaccine helped?) She was on the doxy for 3 weeks, but no change in her lepto reading, which the vet says it indicates that her exposure was some time ago, but could have resulted in some kidney damage which may or may not come back to normal. Her urine will also be tested in a few weeks for its diluteness as well as to see if she is carrying the bacteria (I sure hope not!). Of course, I'm always super careful when coming in contact with her urine, but more so since the lepto diagnosis. I know to see my dr immediately if I start to develop any flu-like symptoms. I'm just hoping that her incontinence continues to improve and that she isn't a carrier. (fingers crossed!!). I am truly sorry to hear about your dog. My previous dog was fine until I thought her breathing sounded different. She had a tumor and was gone in a week. It's a real painful thing to go through.
 

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Just an update, Dolly started on Proin 2/7/14. She has had no accidents!! Next week, she will have a follow up urine test to retest whether her urine is still dilute or whether her kidneys have healed. They will also check to make sure lepto bacteria isn't present.
 

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Thank you for updating us. We really appreciate hearing how things come out, and in this case the news looks very positive so far! :)
 

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its good that has helped the urine incontience!
 

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Just a quick update on the urine test: Her urine is better, still dilute, but in the normal range. Apparently, it is barely normal, so there may be some followup kidney treatment when the specialist vet gets the results. Urine is NEGATIVE for lepto bacteria, so I don't need to worry about her being a carrier! Still have no idea when or how she got lepto. If she already had it when I got her Jul 2012 and she then got the vacccination, I would have thought it could have killed her? Signs indicate that it was an old, not recent, exposure to lepto. Specialist vet thought she probably wouldn't get lepto again (I hope so!). Think we're coming into the home front on this one!
 
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