If he's not normally an anxious dog, I would start with a trip to the vet to make sure there isn't anything medical going on.
Otherwise, it's very possible that he hears or smells something that you just don't. Have you tried a fan/music/white noise machine? An Adaptil diffuser in the bedroom may help too.
Otherwise, it's very possible that he hears or smells something that you just don't. Have you tried a fan/music/white noise machine? An Adaptil diffuser in the bedroom may help too.