Nope, my dog had a bad habit of eating gross things in the backyard, including mulberries. This once lead to explosive vomiting and diarrhea while I was at work, unbeknownst to me. Once the crate was fully clean life went back to normal after a few days. She was a bit nervous to go in, but I think she learned not to eat the freaking mullberries. (factual bit--mullberries are not harmful in themselves, but ferment very easily, so her reaction was most likely more of an intoxication reaction)