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It will depend on how inbred the siblings' parents were to some degree and what kind of health problems might be in the lines.

A single brother-sister mating without a lot of previous inbreeding and otherwise healthy, the puppies may very well be totally fine. But probably a very good idea to spay/neuter at this stage so it doesn't happen again.

A brother-sister mating with a lot of inbreeding or line breeding and/or health problems that may be magnified by being doubled up may have a lot of problems.

(Although sadly in many of these small breeds there are health problems that are pretty endemic anyway and it's hard NOT to double up.)
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