Emma started her new anxiety med Amitriptyline last week. She's on 50mg twice daily. She is extremely hyper since starting this medication. Generally when we run I will take the e-collar off and wrap her leg so she doesn't have the flopping around. Before starting this med she would lick the wrap a few times and then leave it alone. Since starting the med I haven't even been able to leave the e-collar off at all. She will not leave the place on her leg alone, one day she even pushed the wrap down her leg to get to the spot underneath it. I have upped her exercise even more, but it's not helping. She's getting into things, which she hasn't done in 2 years. I called her Vet about it yesterday and she upped the med from one 50mg twice daily to 1 50mg tab and 1/4 of tab twice daily. She said we'll give her til the end of this bottle and if she is still having the same reaction we'll go ahead and try the Prozac. I'm just wondering if it's too early to take her off of it, and maybe we should give her a little longer. But, it seems like it's having an adverse affect on her and making her more OCD. Has anyone ever experienced this?