MDR1 and heartworm prevention only Collies?

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MDR1 and heartworm prevention only Collies?

This is a discussion on MDR1 and heartworm prevention only Collies? within the Dog Health forums, part of the Keeping and Caring for Dogs category; I recently spoke to a breeder who was told by her vet that only Collies have a true sensitivity to certain heartworm meds. This breeder ...

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Old 06-04-2017, 10:27 AM
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MDR1 and heartworm prevention only Collies?

I recently spoke to a breeder who was told by her vet that only Collies have a true sensitivity to certain heartworm meds. This breeder breeds Aussies and does not bother to test for MDR1 and uses whatever kind of heartworm prevention she likes. She hasn't had any problems this far. However, I' m wondering if this could have an effect on this dog's puppies at some point. However, if only Collies are susceptible, then it's irrelevant.
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Old 06-04-2017, 11:17 PM
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unless you are using a weird, off label heart worm preventative, the products containing Ivermectin have far too little to be a danger to any MDR1 dogs, collies included. That may not keep some from being paranoid about collies and micro doses of Ivermectin and for those there are other products containing Milbemycin that are Ivermectin-free (though really those products are riskier if you do not first test your pet to make sure they do not already have an infection... milbemycin is tough on dogs with active infections while micro dose ivermectin is safe for those dogs- even included in part of their treatment protocol sometimes).
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Old 06-05-2017, 07:20 AM
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When I got Forbes his breeder told me that she had not tested for MDR1 but that she, as a precaution, does not use any Ivermectin products with him or any of her aussies or collies just to be sure. Her rational was it was a $300 test to test for something that is easily preventable. From my research it is not only in Collies, but in Aussies as well as many other herding type breeds.
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Old 06-05-2017, 10:09 AM
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From my understanding and research it really is only the livestock dosing of Ivermectin (and consequently their feces) that causes any real problems. Levi was tested (negative) but Heidi wasn't and I use Ivermectin based products for both with no issues.
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Old 06-06-2017, 06:09 AM
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Actually, the MDR1 gene is present in several herding breeds, such as English Shepherds. The general rule for Ivermectin is, "If they have white feet, don't treat".

We haven't tested our smooth collies, but just avoid Ivermectin as a precaution. We use Interceptor as a heart worm preventative, and Simpleguard 3 as monthly flea and tick treatment.
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