Sudden Hindquarter Paralysis - No Known Cause

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Sudden Hindquarter Paralysis - No Known Cause

This is a discussion on Sudden Hindquarter Paralysis - No Known Cause within the Dog Health forums, part of the Keeping and Caring for Dogs category; My 8 year old standard Manchester Terrier became suddenly paralyzed in her hindquarters yesterday morning at 2am. She could not stand and was shaking. I ...

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Old 05-24-2012, 09:54 PM
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Sudden Hindquarter Paralysis - No Known Cause

My 8 year old standard Manchester Terrier became suddenly paralyzed in her hindquarters yesterday morning at 2am. She could not stand and was shaking. I took her to the vet at 9:30am - they ran bloodwork checked her out and referred us to a neurologist for possible stroke or ruptured disc. We took her to the specialist who ordered an MRI. The results showed NO stroke and NO ruptured disc. They can see a bit of "abnormality" on her spinal cord. Possible causes are autoimmune disease, cancer, or infection - in that order. They did a spinal tap last night and were gave her steriods. They got the spinal tap results back and ruled out an infection, so they are treating her for autoimmune disease - she isn't showing any signs of improvement yet...I am soooo worried about my little girl and am trying to find others that have had this issue.
She has not had any vaccinations recently, has not eaten macadamia nuts (I hate them!). I did put SimpleGuard flea medicine on her Friday night (it is comparable to K9 Advantix). Thanks for any help you can provide...my heart is broken...
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Old 05-24-2012, 10:08 PM
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I think that most of the time if its a spinal stroke they can regain mobility with physical therapy. Good luck, and I hope she can get back to normal.
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Old 05-25-2012, 09:51 AM
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Do you live where there are ticks? Did they ultrasound for a thrombus(blood clot)?
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Old 05-25-2012, 12:43 PM
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Did you happen to apply a flea and tick topical like advantix?
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Old 05-25-2012, 10:54 PM
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I think giving her steroids was smart given that no lesions were seen on the MRI.

Don't know where you live, so this may not be an issue for you but there is something called "Tick Paralysis" which may be a possibility.
Merck Veterinary Manual

Do a VERY thorough search all over her to see if you can find any ticks and remove them immediately. Save them in a jar for identification by your vet.


What part of her did they MRI?

Checking for a thrombus is a good idea but it may not be present any longer. That being said, signs of a spinal stroke may not be either.

How are her front legs? Normal? Weak?
Are her back legs totally paralyzed? Does she have any movement? Does she have deep pain?

I'd think if it had to do with the simpleguard you applied, it would have happened quicker but I wouldn't take that off of my list of potential reasons.
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Old 05-25-2012, 11:31 PM
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PS- Has she only been given steroids? Is she on any other immunosuppressants?
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Old 05-28-2012, 08:48 PM
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Thank you for all the replies! I got a bit sidetrack caring for my baby girl this weekend. We picked Kilee up from the specialist Saturday afternoon. They have completely ruled out stroke, cancer, infection, disc issues, tick paralysis, insect/animal bit, FCE, and a ton of other things I have on her paperwork. They ran many tests (blood, physical, and MRI). The neurologist "suspects" GME, but he is still not sure and they are saying her outlook is bleak and she probably will not recover. She is completely paralyzed in her hindquarters, she cannot stand on her own. She is eating fine, drinking fine. I help her express her bladder, which is pretty easy and she is having normal bowel movements (not messy!) involuntary. She is very alert, can bark. Watches us constantly in the house. Her front legs work fine. She even climbed 10 stairs this afternoon while we held her back legs up in the air with the use of a towel - and she darted across the yard with me trying to keep up. Her mind is completely fine. She is on a steriod only. What is immunosuppressants? I see it when I look it up, but not sure she should have these? Let me know what you think... I will try anything at this point. I hate not knowing - that is really bothering me and consuming me. I have found a ton of somewhat related issues from flea/tick medicine containing permethrin...which, yes...that is in the Simple Guard I put on her 103 hours prior to her suddenly collapsing. I am at a loss. I filed a case w/ CEVA the manufacturer, they were suppose to call the vet and I found out they did not...I will be following up tomorrow. I can think of no other reason...and she is not a classic GME patient - and the vet says this too - they just don't know what else it could be... Thanks for any further help you have. Tamra
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Old 05-28-2012, 09:58 PM
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[quote= I have found a ton of somewhat related issues from flea/tick medicine containing permethrin...which, yes...that is in the Simple Guard I put on her 103 hours prior to her suddenly collapsing. I am at a loss. I filed a case w/ CEVA the manufacturer, they were suppose to call the vet and I found out they did not...I will be following up tomorrow. I can think of no other reason...and she is not a classic GME patient - and the vet says this too - they just don't know what else it could be... Thanks for any further help you have. Tamra[/QUOTE]

I have seen many posts about the loss of mobility connected to flee products.
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Old 05-28-2012, 10:07 PM
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If they suspect GME, they should also put her on Cyclosporin at the very least but ideally they'd also treat her with an infusion of Cytosar ASAP. GME needs immunosuppresants and she'll be on them for the rest of her life, with frequent hospitalizations for Cytosar infusions.

GME can affect any part of the CNS-- it is often times brain related but can be spinal as well.

I would ask the vet about the Cytosar and Cyclosporin if they're thinking GME.
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Old 05-28-2012, 10:08 PM
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PS- If it is GME, her long-term prognosis isn't good BUT if treated appropriately she may recover to have some great quality time with you. Median lifespan can be anywhere from 12-16 months or longer with treatment.
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